By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is
the loss of mental ability, severe enough to interfere with people's
every life and Alzheimer's disease is the most common type of dementia
in aging people.
V. Preventions
C. Phytochemicals Against Dementia
C.2. Gingerole
Gingerole, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in
fresh ginger. and in variety of other plants. The herb has been used
for treatment of nausea and vomiting of pregnancy, motion sickness,
rheumatoid arthritis, relieve migraine, etc. in folk medicine.
1. Antioxidant and anti-inflammatory effects
Chemical
constituents of
Zingiber officinale Rosc.(Zingiberaceae) showed to attenuate oxidative
stress, through its scavenging, and inhibiting superoxide and hydroxyl
radicals of ROS species(310), via nephroprotective
effect on mediation of oxidative stress, inflammatory processes, and
renal dysfunction(311).
2. Dementia
Ginger(70%
aqueous/methanolic extract of dried ginger (Zo.Cr)) beside induced
spasmolytic activity in stomach fundus in treating dementia in South
Asia, it also inhibited butyrylcholinesterase (BuChE) in improvement of
cognitive performance patients with dementia(4) and Vascular dementia (VaD)(315), probably through cholinergic anti-inflammatory pathway in reduced production of amyloid-β(316).
C.3. Naringenin
Naringenin, a flavanone, belonging to the red, blue, purple
pigments of Flavonoids (polyphenols) found predominantly in citrus
fruits is considered as one of powerful antioxidant with many health
benefits.
1. Antioxidant, free radical scavenging
Naringin
showed to reduce DNA damage through its antioxidant capacities in
scavenging free radicals hydroxyl and superoxide(317). Cognitively, naringenin
ameliorates Alzheimer's disease (AD)-type neurodegeneration(318) by
improving learning and memory ability of patient with early onset of the
diseases(319). Pharmacologically, the phytochemical was found to be a
potential anticancer, antimutagenic, anti-inflammatory, antiproliferative and antiatherogenic agent(320).
2. Anti-inflammatory effects(320)
Neuroinflammation
is considered as a constant event in Alzheimer's disease (AD), with no
evidences for its direct involvement in development(322). In diabetic mice model, naringenin
exhibited its anti inflammatory activity in lowering blood glucose and
urea nitrogen, increasing insulin level and creatinine clearance(321),
probably through inhibition of iNOS protein and anti inflammatory pathways(323).
3. Immunity
Adaptive and innate immune deficit were shown to
associate with cognitive dysfunction in patients with AD and mild
cognitive impairment (MCI)(325). Naringenin,
stimulated the production T cells in regulating the immune system, in
suppression of allergies and autoimmune diseases(324) which are
considered as Alzheimer's and Parkinson's disease variants(326).
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References
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375
(314) http://www.ncbi.nlm.nih.gov/pubmed/18812031
(315) http://www.ncbi.nlm.nih.gov/pubmed/24727881
(316) http://www.ncbi.nlm.nih.gov/pubmed/24359497
(317) http://www.ncbi.nlm.nih.gov/pubmed/20394007
(318) http://www.ncbi.nlm.nih.gov/pubmed/22898296
(318) http://www.ncbi.nlm.nih.gov/pubmed/25501296
(319) http://www.ncbi.nlm.nih.gov/pubmed/24337945
(320) http://www.ncbi.nlm.nih.gov/pubmed/25501296
(321) http://www.ncbi.nlm.nih.gov/pubmed/22117528
(322) http://www.ncbi.nlm.nih.gov/pubmed/23841061
(323) http://www.ncbi.nlm.nih.gov/pubmed/18274639
(324) http://www.ncbi.nlm.nih.gov/pubmed/22324845
(325) http://www.ncbi.nlm.nih.gov/pubmed/25201785
(326) http://www.ncbi.nlm.nih.gov/pubmed/24786080
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