Thursday, June 8, 2017

Thyroid hormone: Resistance to Thyroid Hormone and Episodes of Thyrotoxicosis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                                 Thyroid hormone



Thyroid hormone (triiodothyronine (T3) and thyroxine (T4)), produced by the thyroid gland, plays an important role in regulation of metabolism, including directly boosts energy metabolism and triggers rapid protein synthesis and regulates mitochondrial gene transcription, etc. Iodine is necessary for the production of T3and T4, deficiency of Iodine can lead to enlarge thyroid grand and goitre.


     Thyroid hormone: Resistance to Thyroid Hormone and Episodes of Thyrotoxicosis


In the study of a 44-year-old Japanese woman with resistance to thyroid hormone, which was confirmed by the P453A mutation in the thyroid hormone receptor ß (TRß) gene, showed a slight elevation of the basal levels of thyroid hormones, which indicated that her pituitary resistance to thyroid hormone was mild. She experienced a slight exacerbation of hyperthyroxinemia concomitant with TSH suppression, showed that Mild pituitary resistance to thyroid hormone can be overcome by slight exacerbation of hyperthyroxinemia during mild thyrotoxicosis. When pituitary resistance is severe and TSH is not suppressed, thyrotoxicosis may be overlooked(29).





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