Tuesday, October 3, 2017

Hormone Histamine: Histamine and noradrenaline and acetylcholine

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                                 Hormone Histamine

Histamine, found within granules of basophils and mast cells (>90% of body stores) is a biogenic amine and an organic nitrogen compound that occurs to various degrees in many foods such as cherries to about 0.17-13.46 ng/g, bananas and grapes, rice and cereals, herbs, olive oil, wine, beer, etc.. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity(a). the hormone, as a neurotransmitter is involved in regulating physiological function in the gut and immune response to foreign pathogens.

     Histamine: Histamine and noradrenaline and acetylcholine



In the study the effects of different histamine concentrations (1 X 10(-6) to 1 X 10(-4)M) on the contractile effects of noradrenaline and acetylcholine on isolated smooth-muscle preparations from rats, showed that histamine increases 2.6 to 16.2 times the noradrenaline concentrations needed for inducing 50 per cent of the maximum contractile response of the anococcygeal muscle. The interaction between noradrenaline and histamine on this smooth-muscle preparation is not competitive. Histamine in the concentrations applied does not influence the contractile effects of noradrenaline on vas deferens and of acetylcholine on tracheal smooth-muscle preparation. In rat anococcygeal muscle histamine most probably influences the contractile effects of noradrenaline and acetylcholinethrough allosteric interaction with their receptors(26).



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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17490952
(26) http://www.ncbi.nlm.nih.gov/pubmed/7315388 

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