Thursday, October 19, 2017

Hormone Melatonin: Melatonin in oral health and disease

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                                 Hormone Melatonin

Melatonin, also known as N-acetyl-5-methoxytryptamine, a hormone secreted by the pineal gland in the brain with functions of regulating sleep cycles, other hormones, timing in secretion of female hormones that affect the menstrual cycle, etc. The levels of the circulating hormone vary in a daily cycle, depending to the circadian rhythm is an internal 24-hour “clock”.

     Hormone Melatonin: Melatonin in oral health and disease



According to the study of Faculty of Dentistry, Zonguldak Karaelmas University, melatonin has immunomodulatory and antioxidant activities, stimulates the proliferation of collagen and osseous tissue, and acts as a protector against cellular degeneration associated with aging and toxin exposure. Arising out of its antioxidant actions, melatonin protects against inflammatory processes and cellular damage caused by the toxic derivates of oxygen. As a result of these actions, melatonin may be useful as a coadjuvant in the treatment of certain conditions of the oral cavity. However, the most important effect of melatoninseems to result from its potent antioxidant, immunomodulatory, protective, and anticancer properties. Thus, melatonin could be used therapeutically for instance, locally, in the oral cavity damage of mechanical, bacterial, fungal, or viral origin, in postsurgical wounds caused by tooth extractions and other oral surgeries. Additionally, it can help bone formation in various autoimmunological disorders such as Sjorgen syndrome, in periodontal diseases, in toxic effects of dental materials, in dental implants, and in oral cancers(13). Other researchers suggested that strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease,various other neurological and stressful conditions, pain, cardiovascular diseases, cases of cancer, endocrine and metabolic disorders, in particular diabetes type 2(14). Clinical trials have shown that melatonin is efficient in preventing cell damage under acute (sepsis, asphyxia in newborns) and chronic states (metabolic and neurodegenerative diseases, cancer, inflammation, aging). The beneficial effects of melatonin can be explained by its properties as a potent antioxidant and antioxidant enzyme inducer, a regulator of apoptosis and a stimulator of immune functions(15).

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Sources
(13) http://www.ncbi.nlm.nih.gov/pubmed/22792106
(14) http://www.ncbi.nlm.nih.gov/pubmed/22724080
(15) http://www.ncbi.nlm.nih.gov/pubmed/22511571

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