Friday, October 27, 2017

Hormone Melatonin: Melatonin in experimental seizures and epilepsy

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                                 Hormone Melatonin

Melatonin, also known as N-acetyl-5-methoxytryptamine, a hormone secreted by the pineal gland in the brain with functions of regulating sleep cycles, other hormones, timing in secretion of female hormones that affect the menstrual cycle, etc. The levels of the circulating hormone vary in a daily cycle, depending to the circadian rhythm is an internal 24-hour “clock”.

     Hormone Melatonin: Melatonin in experimental seizures and epilepsy



Although melatonin is approved only for the treatment of jet-lag syndrome and some types of insomnia, clinical data also suggest that it is effective in the adjunctive therapy of osteoporosis, cataract, sepsis, neurodegenerative diseases, hypertension, and even cancer. In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy. Its additional benefits include improved physical, emotional, cognitive, and social functions. On the other hand, melatonin has been shown to induce electroencephalographic abnormalities in patients with temporal lobe epilepsy and increase seizure activity in neurologically disabled children. The hormone showed very low toxicity in clinical practice, according to the study by Department of Pathophysiology, Medical University, PL 20-090 Lublin, Jaczewskiego 8, Poland(22).


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Sources
(22) http://www.ncbi.nlm.nih.gov/pubmed/21441606

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