Monday, November 13, 2017

Hormone Norepinephrine: Olanzapine and dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                        Hormone Catecholamines


Catecholamines, derived from the amino acid tyrosine, produced by the adrenal glands, which are found on top of the kidneys. are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. The hormone are released into the blood during times of physical or emotional stress.

     Hormone Norepinephrine: Olanzapine and dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum




The in vivo effects of olanzapine on the extracellular monoamine levels in rat prefrontal cortex (Pfc), nucleus accumbens (Acb) and striatum (Cpu) were investigated by means of microdialysis. In the study of the effect of Sequential doses of olanzapine at 0.5, 3 and 10 mg/kg (s.c.) dose-dependently in the extracellular dopamine (DA) and norepinephrine (NE) levels in all three brain areas, found that in the case of sequential dosing olanzapine more effectively enhances DA and NE release in the Pfc than in the subcortical areas, which may have an impact on its atypical antipsychotic actions(11).




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Sources
(11) http://www.ncbi.nlm.nih.gov/pubmed/9551772

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